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Results for "

VML 251-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1658S
    Frovatriptan-d3 hydrochloride

    (R)-Frovatriptan-d<sub>3sub> hydrochloride; SB 209509-d<sub>3sub> hydrochloride; VML 251-d<sub>3sub> hydrochloride

    		 5-HT Receptor Neurological Disease
    Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
    Frovatriptan-d3 hydrochloride
  • HY-B1658BS
    Frovatriptan-d3 succinate

    (R)-Frovatriptan-d<sub>3sub> succinate; SB 209509-d<sub>3sub> succinate; VML 251-d<sub>3sub> succinate

    		 Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Frovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].
    Frovatriptan-d3 succinate

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